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Table 1 List of top dysregulated mirnas and their predicted gene targets.

From: Potential role of miR-9 and miR-223 in recurrent ovarian cancer

MiRNA

Fold change

Expression in recuurent vs Primary

MiRGen

Transcriptome study13

miR-223

11.35571231

Upregulated

FGFR2, EGF, S100A3, KRAS, TGFB2, IFNB1, SPINK5, E2F1

SEPTIN6, MMP9, USF2

miR-9

3.886456405

Downregulated

FGF18, FGF10, BCL2, BCL6, BRAF, CLDN14, CLDN6, SEPTIN10

ZNF, PVRL2, LASS4, BCL2, CLDN, FGF

  1. These represent genes predicted by MiRGen well characterised in ovarian carcinogenesis and also genes identified in an earlier study performed by our group [13].
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Molecular Cancer

ISSN: 1476-4598