Skip to main content

Table 4 ERCC2 Asp312Asn, ERCC2 Lys751Gln polymorphisms and potential ovarian cancer risk factors

From: DNA repair gene ERCC2 polymorphisms and associations with breast and ovarian cancer risk

  Age at menarche = 13 years Age at menarche > 13 years
Genotype Cases (%) Controls (%) OR (CI 95%) P value Cases (%) Controls (%) OR (CI 95%) P value
ERCC2 Lys751Gln         
Lys/Lys 1 (3) 87 (13) 1.00 (reference)   0 (0) 32 (10) -  
Lys/Gln 21 (57) 303 (46) 6.03 (1.02–35.78)   10 (71) 175 (52) 1.00 (reference)  
Gln/Gln 15 (41) 271 (41) 4.82 (0.6–30.62) 0.14 4 (29) 127 (38) 0.55 (0.17–1.77) 0.32
  No OC* users OC users
Genotype Cases (%) Controls (%) OR (CI 95%)   Cases (%) Controls (%) OR (CI 95%)  
ERCC2 Asp312Asn         
Asp/Asp 13 (35) 215 (50) 1.00 (reference)   5 (50) 243 (43) 1.00 (reference)  
Asp/Asn 23 (62) 176 (41) 2.16 (1.08–4.33)   5 (50) 242 (43) 1.00 (0.29–3.51)  
Asn/Asn 1 (3) 40 (9) 0.41 (0.06–3.05) 0.032 0 (0) 78 (14) - 0.45
ERCC2 Lys751Gln         
Lys/Lys 0 (0) 39 (9) -   0 (0) 80 (14) -  
Lys/Gln 27 (73) 198 (46) 1.00 (reference)   4 (40) 248 (44) 1.00 (reference)  
Gln/Gln 10 (27) 195 (45) 0.38 (0.18–0.78) 0.0085 6 (60) 235 (42) 1.58 (0.45–5.62) 0.7**
  BMI ≤ 25 BMI >25
Genotype Cases (%) Controls (%) OR (CI 95%)   Cases (%) Controls (%) OR (CI 95%)  
ERCC2 Asp312Asn         
Asp/Asp 18 (47) 311 (45) 1.00 (reference)   3 (23) 147 (48) 1.00 (reference)  
Asp/Asn 19 (50) 292 (43) 1.12 (0.58–2.18)   9 (69) 126 (41) 3.5 (1.00–12.26)  
Asn/Asn 1 (3) 84 (12) 0.21 (0.03–1.29) 0.19 1 (8) 34 (11) 1.44 (0.15–14.11) 0.13
ERCC2 Lys751Gln         
Lys/Lys 1 (3) 84 (12) 1.00 (reference)   0 (0) 35 (11) -  
Lys/Gln 21 (55) 313 (45) 5.64 (0.93–33.99)   10 (77) 133 (43) 1.00 (reference)  
Gln/Gln 16 (42) 291 (42) 4.62 (0.72–29.53) 0.17 3 (23) 139 (45) 0.29 0.08–0.99) 0.048
  Waist-to-hip ratio = 0.85 Waist-to-hip ratio > 0.85
Genotype Cases (%) Controls (%) OR (CI 95%)   Cases (%) Controls (%) OR (CI 95%)  
ERCC2 Lys751Gln         
Lys/Lys 1 (4) 102 (13) 1.00 (reference)   0 (0) 17 (8) -  
Lys/Gln 19 (70) 341 (44) 5.68 (0.94–34.25)   12 (50) 105 (49) 1.00 (reference)  
Gln/Gln 7 (26) 338 (43) 2.11 (0.27–16.57) 0.02 12 (50) 92 (43) 1.14 (0.49–2.66) 0.76
  1. * OC = Oral Contraceptive
  2. ** after Yates correction