Table 4 ERCC2 Asp312Asn, ERCC2 Lys751Gln polymorphisms and potential ovarian cancer risk factors
From: DNA repair gene ERCC2 polymorphisms and associations with breast and ovarian cancer risk
Age at menarche = 13 years | Age at menarche > 13 years | |||||||
|---|---|---|---|---|---|---|---|---|
Genotype | Cases (%) | Controls (%) | OR (CI 95%) | P value | Cases (%) | Controls (%) | OR (CI 95%) | P value |
ERCC2 Lys751Gln | ||||||||
Lys/Lys | 1 (3) | 87 (13) | 1.00 (reference) | 0 (0) | 32 (10) | - | ||
Lys/Gln | 21 (57) | 303 (46) | 6.03 (1.02–35.78) | 10 (71) | 175 (52) | 1.00 (reference) | ||
Gln/Gln | 15 (41) | 271 (41) | 4.82 (0.6–30.62) | 0.14 | 4 (29) | 127 (38) | 0.55 (0.17–1.77) | 0.32 |
No OC* users | OC users | |||||||
Genotype | Cases (%) | Controls (%) | OR (CI 95%) | Cases (%) | Controls (%) | OR (CI 95%) | ||
ERCC2 Asp312Asn | ||||||||
Asp/Asp | 13 (35) | 215 (50) | 1.00 (reference) | 5 (50) | 243 (43) | 1.00 (reference) | ||
Asp/Asn | 23 (62) | 176 (41) | 2.16 (1.08–4.33) | 5 (50) | 242 (43) | 1.00 (0.29–3.51) | ||
Asn/Asn | 1 (3) | 40 (9) | 0.41 (0.06–3.05) | 0.032 | 0 (0) | 78 (14) | - | 0.45 |
ERCC2 Lys751Gln | ||||||||
Lys/Lys | 0 (0) | 39 (9) | - | 0 (0) | 80 (14) | - | ||
Lys/Gln | 27 (73) | 198 (46) | 1.00 (reference) | 4 (40) | 248 (44) | 1.00 (reference) | ||
Gln/Gln | 10 (27) | 195 (45) | 0.38 (0.18–0.78) | 0.0085 | 6 (60) | 235 (42) | 1.58 (0.45–5.62) | 0.7** |
BMI ≤ 25 | BMI >25 | |||||||
Genotype | Cases (%) | Controls (%) | OR (CI 95%) | Cases (%) | Controls (%) | OR (CI 95%) | ||
ERCC2 Asp312Asn | ||||||||
Asp/Asp | 18 (47) | 311 (45) | 1.00 (reference) | 3 (23) | 147 (48) | 1.00 (reference) | ||
Asp/Asn | 19 (50) | 292 (43) | 1.12 (0.58–2.18) | 9 (69) | 126 (41) | 3.5 (1.00–12.26) | ||
Asn/Asn | 1 (3) | 84 (12) | 0.21 (0.03–1.29) | 0.19 | 1 (8) | 34 (11) | 1.44 (0.15–14.11) | 0.13 |
ERCC2 Lys751Gln | ||||||||
Lys/Lys | 1 (3) | 84 (12) | 1.00 (reference) | 0 (0) | 35 (11) | - | ||
Lys/Gln | 21 (55) | 313 (45) | 5.64 (0.93–33.99) | 10 (77) | 133 (43) | 1.00 (reference) | ||
Gln/Gln | 16 (42) | 291 (42) | 4.62 (0.72–29.53) | 0.17 | 3 (23) | 139 (45) | 0.29 0.08–0.99) | 0.048 |
Waist-to-hip ratio = 0.85 | Waist-to-hip ratio > 0.85 | |||||||
Genotype | Cases (%) | Controls (%) | OR (CI 95%) | Cases (%) | Controls (%) | OR (CI 95%) | ||
ERCC2 Lys751Gln | ||||||||
Lys/Lys | 1 (4) | 102 (13) | 1.00 (reference) | 0 (0) | 17 (8) | - | ||
Lys/Gln | 19 (70) | 341 (44) | 5.68 (0.94–34.25) | 12 (50) | 105 (49) | 1.00 (reference) | ||
Gln/Gln | 7 (26) | 338 (43) | 2.11 (0.27–16.57) | 0.02 | 12 (50) | 92 (43) | 1.14 (0.49–2.66) | 0.76 |