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Figure 5 | Molecular Cancer

Figure 5

From: Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas

Figure 5

Tumor presence in bone marrow is blocked by L-744,832. The presence of IgMa positive transgenic lymphoma cells in the bone marrow was measured using flow cytometry. C57BL/6 mice were transplanted with 106 tumor cells from an Eμ-Myc/BCRHEL/HEL mouse (panels b-d) or left unmanipulated (panel a). Transplant recipient mice were left untreated (panel b) or treated with L-744,832 for either 28 days (panel c) or for the final 7 days of the experiment (panel d). Bone marrow was harvested from the femurs and tibias of wild-type mice (panel a), untreated tumor recipient mice (panel b), 28-day treated tumor recipient mice (panel c) or 7-day treated tumor recipient mice (panel d). Isolated cells were stained for IgMa and analyzed by flow cytometry. The mean percentage and standard deviation of IgMa positive cells are indicated above each histogram for 4 mice in each treatment group.

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