Figure 2

Empirical analysis of genetic interactions acting on tumorigenesis. Pre-processed and normalized data were taken from Chin et al. [60]. White squares represent missing data. Log expression ratios are relative to tumors that do not show amplification at 8q24 or 20q13. Average expression values are shown for each gene probe (not detailed) in each tumor set (8q24/20q13, 8q24 or 20q13 amplification). Transcript correlations were calculated using the Pearson correlation coefficient and adjusted P values with a false discovery rate of 5%; only significant correlations with Q values < 0.05 are shown, except for the 8q24/20q13 co-amplification set (dashed line; Q ~0.07).