Figure 3
Examples of matrix screens of genetic interactions of interest in studying cancer susceptibility, progression and treatment: (A) Interactions are identified in standard cancer cell lines by depleting one gene at a time and through quantitation of emerging phenotypes; (B) Interactions are identified between genes involved in the DNA repair processes, with quantitation of emerging phenotypes highlighting repair subcategories; and (C) Interactions are revealed between known tumor suppressor genes and oncogenes, with quantitation of emerging phenotypes highlighting different properties of the neoplastic process.