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Figure 3 | Molecular Cancer

Figure 3

From: Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile

Figure 3

Unsupervised clustering of 4 gliomas with 1p19q codeletion, 9 gliomas with EGFR amplification, 6 glioblastoma cancer stem cells cell lines and 10 normal brain tissue samples. Unsupervised hierarchical clustering was performed using the 1366 probe sets whose expression varied the most across the 29 samples (probe sets with a robust coefficient of variation superior to the 97.5th percentile). Samples and genes were clustered using Ward's linkage and 1-Pearson correlation coefficient. For each probe set, data were median-centered (white), with the lowest and highest intensity values in blue and red, respectively. 1p19q = 1p19q codeletion, EGFR = EGFR amplification, CC = corpus callosum, Cx = cortex, CSC = cancer stem cells. The 29 gliomas were classified into 2 groups and 5 subgroups. Gliomas with EGFR amplification were classified with the cancer stem cell lines. Gliomas with 1p19q codeletion were classified with the normal brain samples, however their gene expression pattern was clearly different from the gene expression pattern of the white matter (corpus callosum) and grey matter (cortex) samples.

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