Table 1 Most characteristic genes associated with oligodendrogliomas with 1p19q codeletion
From: Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile
Probe set | Title | Gene Symbol | Gene ontology (biological process) | High expression in: | FD/EGFR | FD/Cx | FD/CC | FD/Stem cells |
|---|---|---|---|---|---|---|---|---|
206785_s_at | Killer cell lectin-like receptor subfamily C, member 1///member 2 | KLRC1//KLRC2 | Cellular defense response | Natural killer cells | 104.2 | 92.1 | 61.4 | 66.7 |
243779_at, 236536_at | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13) | GALNT13 | Protein amino acid O-linked glycosylation | Specifically expressed in neuronal cells | 31.8 | 18.2 | 17.1 | 15.0 |
1558706_a_at, 228890_at | Atonal homolog 8 (Drosophila) | ATOH8 | Regulation of transcription | --- | 26.1 | 30.8 | 21.4 | 27.1 |
240228_at | CUB and Sushi multiple domains 3 | CSMD3 | Integral to membrane | Brain | 22.7 | 11.8 | 13.9 | 15.1 |
207723_s_at | Killer cell lectin-like receptor subfamily C, member 3 | KLRC3 | Cellular defense response | Natural killer cells | 17.9 | 27.3 | 13.1 | 11.3 |
230826_at | Monocyte to macrophage differentiation-associated 2 | MMD2 | Cytolysis | --- | 17.2 | 7.2 | 9.1 | 26.2 |
60474_at, 218796_at | Chromosome 20 open reading frame 42 | C20orf42 | Cell adhesion | Brain (among others) | 16.2 | 37.4 | 29.1 | 19.6 |
231798_at | Noggin | NOG | Nervous system development | --- | 11.2 | 9.2 | 9.5 | 13.6 |
1556599_s_at | Cyclic AMP-regulated phosphoprotein, 21 kD | ARPP-21 | --- | --- | 11.1 | 14.0 | 16.8 | 13.9 |
227845_s_at | Src homology 2 domain containing transforming protein D | SHD | Intracellular signaling cascade | --- | 10.3 | 10.6 | 16.5 | 7.6 |
205289_at, 205290_s_at | Bone morphogenetic protein 2 | BMP2 | Positive regulation of astrocyte differentiation | Brain (among others) | 10.1 | 30.7 | 25.9 | 12.7 |
205330_at | Meningioma (disrupted in balanced translocation) 1 | MN1 | Negative regulation of progression through cell cycle | Ubiquitously expressed | 8.4 | 5.8 | 9.5 | 15.9 |
219668_at | Ganglioside-induced differentiation-associated protein 1-like 1 | GDAP1L1 | --- | --- | 8.4 | 4.2 | 9.1 | 7.9 |
204530_s_at | Thymus high mobility group box protein TOX | TOX | Regulation of transcription | --- | 8.3 | 6.6 | 12.5 | 6.0 |
228790_at, 221959_at | Chromosome 8 open reading frame 72 | C8orf72 | --- | --- | 7.6 | 14.6 | 19.1 | 36.6 |
232136_s_at | Cortactin binding protein 2 | CTTNBP2 | --- | Brain | 5.4 | 7.1 | 4.3 | 6.5 |
233136_at | Poly(A) binding protein, cytoplasmic 5 | PABPC5 | --- | Fetal brain | 5.4 | 4.6 | 4.6 | 4.9 |
219093_at | Phosphotyrosine interaction domain containing 1 | PID1 | --- | Brain (among others) | 5.1 | 12.3 | 23.0 | 4.0 |
205773_at | Cytoplasmic polyadenylation element binding protein 3 | CPEB3 | Nucleotide binding | --- | 4.5 | 4.0 | 4.8 | 5.4 |
1560265_at | Glutamate receptor, ionotropic, kainate 2 | GRIK2 | Regulation of synaptic transmission | Cerebellum, cerebral cortex | 4.5 | 3.7 | 5.9 | 7.1 |
238526_at | RAB3A interacting protein (rabin3) | RAB3IP | protein transport | Brain (among others) | 4.4 | 5.9 | 7.2 | 3.2 |
213001_at, 219514_at | Angiopoietin-like 2 | ANGPTL2 | Development | Heart among others | 3.9 | 12.2 | 6.0 | 4.0 |
229590_at | Ribosomal protein L13 | RPL13 | Translation | --- | 3.8 | 3.7 | 3.8 | 2.8 |
206117_at | Tropomyosin 1 (alpha) | TPM1 | Cell motility | Muscle among others | 3.6 | 4.1 | 4.2 | 3.3 |
202315_s_at, 217223_s_at | Breakpoint cluster region | BCR | Regulation of Rho protein signal transduction | --- | 3.3 | 4.4 | 7.6 | 4.5 |
234268_at | Solute carrier family 2 (facilitated glucose transporter), member 13 | SLC2A13 | Carbohydrate transport | Brain | 3.1 | 3.4 | 4.1 | 3.2 |
228813_at, 204225_at | Histone deacetylase 4 | HDAC4 | Nervous system development | Ubiquitously expressed | 3.1 | 2.6 | 3.9 | 4.4 |
209511_at | Polymerase (RNA) II (DNA directed) polypeptide F | POLR2F | Regulation of transcription | --- | 3.0 | 6.9 | 4.7 | 3.0 |
213033_s_at, 213032_at | Nuclear factor I/B | NFIB | Regulation of transcription, DNA-dependent, Brain development | --- | 3.0 | 10.7 | 13.8 | 8.2 |
204100_at | Thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) | THRA | Negative regulation of transcription | Brain (among others) | 2.9 | 2.9 | 2.2 | 3.7 |
230198_at | WD repeat domain 37 | WDR37 | --- | --- | 2.8 | 4.0 | 2.8 | 2.6 |
213758_at | Cytochrome c oxidase subunit IV isoform 1 | COX4I1 | Electron transport | Ubiquitously expressed | 2.4 | 2.2 | 2.7 | 3.2 |
221012_s_at | Tripartite motif-containing 8///tripartite motif-containing 8 | TRIM8 | --- | Brain (among others) | 2.3 | 3.1 | 3.2 | 3.2 |
202182_at | GCN5 general control of amino-acid synthesis 5-like 2 (yeast) | GCN5L2 | Regulation of transcription, DNA-dependent | Ubiquitously expressed | 2.3 | 2.5 | 2.4 | 2.3 |
214198_s_at | DiGeorge syndrome critical region gene 2 | DGCR2 | Cell adhesion | Brain (among others) | 2.3 | 3.4 | 5.0 | 2.4 |
225334_at | Chromosome 10 open reading frame 32 | C10orf32 | --- | --- | 2.2 | 3.5 | 4.1 | 3.2 |
210690_at | Killer cell lectin-like receptor subfamily C, member 4 | KLRC4 | Cellular defense response | Natural killer cells | 2.2 | 2.2 | 2.0 | 2.2 |
203938_s_at | TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa | TAF1C | Transcription | --- | 2.1 | 3.2 | 2.6 | 2.1 |
217969_at | Chromosome 11 open reading frame2 | C11orf2 | --- | --- | 2.0 | 2.8 | 3.9 | 3.3 |