Table 2 Real-time RT-PCR study of 22 differentially expressed genes
From: Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile
Gene symbol | Description | Gene ontology | Fold difference of geom means 1p19q/EGFR (microarray)* | Fold difference of geom means 1p19q/EGFR in validation sample set (RT-PCR)** |
|---|---|---|---|---|
AKR1C3 | Aldo-keto reductase family 1, member C3 | Prostaglandin metabolism | 17.5 | 7.1 |
ATOH8 | Atonal homolog 8 (Drosophila) | Regulation of transcription | 26 | 23.5 |
BMP2 | Bone morphogenetic protein 2 | Positive regulation of astrocyte differentiation | 10.1 | 10.2 |
C20ORF42 | Chromosome 20 open reading frame 42 | Cell adhesion | 16.2 | 15.7 |
CTTNBP2 | Cortactin binding protein 2 | --- | 5.4 | 3.9 |
DCX | Doublecortex; lissencephaly, X-linked (doublecortin) | CNS development | 5.9 | 6.3 |
GALNT13 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13) | Protein amino acid O-linked glycosylation | 31.7 | 38.4 |
L1CAM | L1 cell adhesion molecule | Nervous system development | 14.6 | 24.5 |
NCAM1 | Neural cell adhesion molecule 1 | Synaptic transmission | 4.8 | 1.7(NS) |
NOG | Noggin | Nervous system development | 11.2 | 18.4 |
OLIG2 | Oligodendrocyte lineage transcription factor 2 | Nervous system development | 4.7 | 3.7 |
CCNB1 | Cyclin B1 | Mitosis | 0.2 | 0.2 |
CDK2 | Cyclin-dependent kinase 2 | Mitosis | 0.2 | 0.2 |
CHI3L1 | Chitinase 3-like 1 (cartilage glycoprotein-39) | Chitin catabolism | 0.01 | 0.003 |
EGFR | Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | Cell proliferation | 0.1 | 0.2 |
GBP1 | Guanylate binding protein 1, interferon-inducible, 67kDa | Immune response | 0.05 | 0.05 |
IGFBP2 | Insulin-like growth factor binding protein 2, 36 kDa | Regulation of cell growth | 0.02 | 0.01 |
IQGAP1 | IQ motif containing GTPase activating protein 1 | Signal transduction | 0.11 | 0.1 |
PDPN | Podoplanin | Positive regulation of cell motility | 0.02 | 0.008 |
PLAT | Plasminogen activator, tissue | Proteolysis | 0.07 | 0.06 |
POSTN | Periostin, osteoblast specific factor | Cell adhesion | 0.01 | 0.01 |
RNF135 | Ring finger protein 135 | --- | 0.2 | 0.2 |