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Table 2 Real-time RT-PCR study of 22 differentially expressed genes

From: Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile

Gene symbol Description Gene ontology Fold difference of geom means 1p19q/EGFR (microarray)* Fold difference of geom means 1p19q/EGFR in validation sample set (RT-PCR)**
AKR1C3 Aldo-keto reductase family 1, member C3 Prostaglandin metabolism 17.5 7.1
ATOH8 Atonal homolog 8 (Drosophila) Regulation of transcription 26 23.5
BMP2 Bone morphogenetic protein 2 Positive regulation of astrocyte differentiation 10.1 10.2
C20ORF42 Chromosome 20 open reading frame 42 Cell adhesion 16.2 15.7
CTTNBP2 Cortactin binding protein 2 --- 5.4 3.9
DCX Doublecortex; lissencephaly, X-linked (doublecortin) CNS development 5.9 6.3
GALNT13 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13) Protein amino acid O-linked glycosylation 31.7 38.4
L1CAM L1 cell adhesion molecule Nervous system development 14.6 24.5
NCAM1 Neural cell adhesion molecule 1 Synaptic transmission 4.8 1.7(NS)
NOG Noggin Nervous system development 11.2 18.4
OLIG2 Oligodendrocyte lineage transcription factor 2 Nervous system development 4.7 3.7
CCNB1 Cyclin B1 Mitosis 0.2 0.2
CDK2 Cyclin-dependent kinase 2 Mitosis 0.2 0.2
CHI3L1 Chitinase 3-like 1 (cartilage glycoprotein-39) Chitin catabolism 0.01 0.003
EGFR Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) Cell proliferation 0.1 0.2
GBP1 Guanylate binding protein 1, interferon-inducible, 67kDa Immune response 0.05 0.05
IGFBP2 Insulin-like growth factor binding protein 2, 36 kDa Regulation of cell growth 0.02 0.01
IQGAP1 IQ motif containing GTPase activating protein 1 Signal transduction 0.11 0.1
PDPN Podoplanin Positive regulation of cell motility 0.02 0.008
PLAT Plasminogen activator, tissue Proteolysis 0.07 0.06
POSTN Periostin, osteoblast specific factor Cell adhesion 0.01 0.01
RNF135 Ring finger protein 135 --- 0.2 0.2
  1. Fold difference of geometrical means in microarray and in real-time RT-PCR of the 22 genes studied in the independent sample set. * All genes were differentially expressed with a p-value < 0.001 except DCX (p-value = 0.004). * * All genes were differentially expressed with a p-value < 0.05 except when NS (non significant) is specified.