Table 1 Methylation status of 19 CpG sites in the 450 bp promoter region of HLA-G gene in malignant (CA), benign (BN) and normal (NL) ovarian tissue samples.
From: Epigenetic changes within the promoter region of the HLA-G gene in ovarian tumors
CA | -394 | -356 | -290 | -272 | -261 | -241 | -211 | -188 | -186 | -150 | -125 | -121 | -68 | -65 | -62 | -60 | -39 | -27 | -8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
212 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.00 | 0.00 | 0.25 | 0.00 | 0.25 | 0.75 | 0.00 | 0.75 | 0.00 | 0.00 | 0.00 | 0.75 |
229 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.00 | 0.00 | 1.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
183 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.00 | 0.00 | 0.38 | 0.00 | 0.38 | 0.63 | 0.00 | 0.63 | 0.00 | 0.00 | 0.00 | 0.63 |
317 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.60 | 0.60 | 0.80 | 0.00 | 0.80 | 0.20 | 0.20 | 0.80 | 0.00 | 0.60 | 0.00 | 0.40 |
369 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.40 | 0.40 | 0.60 | 0.20 | 0.60 | 0.40 | 0.00 | 1.00 | 0.20 | 0.60 | 0.00 | 0.20 |
413 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.60 | 0.60 | 1.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.80 | 0.00 | 0.60 | 0.00 | 0.20 |
170 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.20 | 0.20 | 1.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.20 | 0.00 | 0.00 |
228 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.75 | 0.75 | 0.75 | 0.00 | 0.75 | 0.25 | 0.25 | 1.00 | 0.00 | 0.75 | 0.00 | 0.25 |
242 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.20 | 0.20 | 0.40 | 0.00 | 0.40 | 0.60 | 0.00 | 0.80 | 0.00 | 0.20 | 0.00 | 0.80 |
AVE | 0.000 | 0.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 0.306 | 0.306 | 0.687 | 0.022 | 0.664 | 0.314 | 0.050 | 0.664 | 0.022 | 0.328 | 0.000 | 0.359 |
BN | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
382 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.00 | 0.00 | 0.40 | 0.00 | 0.40 | 0.60 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.80 |
412 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.60 | 0.80 | 0.80 | 0.00 | 0.80 | 0.20 | 0.00 | 0.83 | 0.00 | 0.60 | 0.00 | 0.00 |
388 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.17 | 0.17 | 0.17 | 0.00 | 0.17 | 0.67 | 0.00 | 1.00 | 0.00 | 0.33 | 0.00 | 0.83 |
416 | 0.20 | 0 | 1 | 1 | 1 | 1 | 1 | 0.40 | 0.40 | 0.60 | 0.00 | 0.60 | 0.40 | 0.00 | 0.80 | 0.00 | 0.40 | 0.00 | 0.60 |
371 | 0.14 | 0 | 1 | 1 | 1 | 1 | 1 | 0.14 | 0.14 | 0.43 | 0.00 | 0.43 | 0.57 | 0.00 | 0.71 | 0.00 | 0.29 | 0.00 | 0.71 |
377 | 0.20 | 0.20 | 0.60 | 1 | 1 | 1 | 1 | 0.40 | 0.60 | 0.60 | 0.20 | 0.60 | 0.20 | 0.00 | 0.60 | 0.00 | 0.60 | 0.00 | 0.00 |
386 | 0.20 | 0 | 1 | 1 | 1 | 1 | 1 | 0.00 | 0.00 | 0.60 | 0.00 | 0.60 | 0.40 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.40 |
400 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.20 | 0.50 | 0.50 | 0.00 | 0.50 | 0.50 | 0.00 | 1.00 | 0.00 | 0.50 | 0.00 | 0.50 |
383 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0.10 | 0.10 | 0.90 | 0.00 | 0.90 | 0.10 | 0.00 | 0.30 | 0.00 | 0.10 | 0.00 | 0.13 |
AVE | 0.082 | 0.022 | 0.956 | 1.000 | 1.000 | 1.000 | 1.000 | 0.223 | 0.301 | 0.556 | 0.022 | 0.556 | 0.404 | 0.000 | 0.694 | 0.000 | 0.313 | 0.000 | 0.441 |
NL | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
492 | 0.40 | 0.40 | 0.40 | 0.60 | 0.80 | 1.00 | 0.80 | 0.00 | 0.20 | 0.20 | 0.20 | 0.20 | 0.40 | 1.00 | 0.20 | 0.20 | 0.00 | 0.00 | 0.20 |
499 | 0.17 | 0.33 | 0.50 | 0.67 | 0.83 | 0.67 | 0.83 | 0.50 | 0.00 | 0.33 | 0.50 | 0.50 | 0.50 | 0.50 | 0.67 | 0.17 | 0.00 | 0.00 | 0.17 |
500 | 0.60 | 0.80 | 0.00 | 0.80 | 0.40 | 0.80 | 0.80 | 0.00 | 0.00 | 0.20 | 0.20 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 |
525 | 0.33 | 0.33 | 0.00 | 1.00 | 1.00 | 1.00 | 0.67 | 0.00 | 0.00 | 0.00 | 0.33 | 0.33 | 0.33 | 0.33 | 0.67 | 0.00 | 0.00 | 0.33 | 0.33 |
AVE | 0.374 | 0.466 | 0.225 | 0.767 | 0.758 | 0.867 | 0.776 | 0.125 | 0.050 | 0.183 | 0.308 | 0.308 | 0.308 | 0.458 | 0.384 | 0.092 | 0.050 | 0.083 | 0.174 |
P-VALUES | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
CA VS NL | <1E-04 | <1E-04 | <1E-04 | 0.001 | 0.011 | 0.025 | <1E-04 | 0.308 | 0.122 | 0.008 | 0.0004 | 0.033 | 0.970 | 0.014 | 0.225 | 0.174 | 0.111 | 0.139 | 0.277 |
BN VS NL | 0.003 | 0.0002 | <1E-04 | 0.001 | 0.011 | 0.025 | <1E-04 | 0.466 | 0.121 | 0.010 | 0.0004 | 0.063 | 0.448 | 0.005 | 0.087 | 0.019 | 0.059 | 0.139 | 0.153 |