TY - JOUR AU - Cheng, Fan AU - McLaughlin, Patricia J. AU - Verderame, Michael F. AU - Zagon, Ian S. PY - 2008 DA - 2008/01/11 TI - The OGF-OGFr axis utilizes the p21 pathway to restrict progression of human pancreatic cancer JO - Molecular Cancer SP - 5 VL - 7 IS - 1 AB - Pancreatic cancer is the 4th leading cause of death from cancer in the U.S. The opioid growth factor (OGF; [Met5]-enkephalin) and the OGF receptor form an inhibitory growth regulatory system involved in the pathogenesis and treatment of pancreatic cancer. The OGF-OGFr axis influences the G0/G1 phase of the cell cycle. In this investigation, we elucidate the pathway of OGF in the cell cycle. SN - 1476-4598 UR - https://doi.org/10.1186/1476-4598-7-5 DO - 10.1186/1476-4598-7-5 ID - Cheng2008 ER -