Figure 8From: Effect of bortezomib on human neuroblastoma: analysis of molecular mechanisms involved in cytotoxicityDown regulation of HSP27 phosphorylation by inhibition of p38 MAPK. The neuroblastoma cell lines SHEP, CLB-Sedp and IMR32 were treated with SB202190 (50 μM) for 30 min prior to culture with different concentrations of bortezomib for 48 h. Expressions of HSP27, P-HSP27, HSP70, HSP90, Mcl1 and Bcl-xl were assessed by Western blot using specific antibodies.Back to article page