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Figure 6 | Molecular Cancer

Figure 6

From: Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells

Figure 6

HDACi repress hypoxia induced VEGF expression. SH-EP cells were stimulated with NaB (20 mM), SAHA (20 μM) or TSA (5 μM), LAN-1 and IMR32 cells were stimulated with NaB (10 mM), SAHA (5 μM) or TSA (1.5 μM), or unstimulated (no) for 24 h under normoxia or hypoxia (1% O2). The bare graphs represent the amount of secreted VEGF in the supernatant normalized by the total amount of protein obtained in the corresponding cell lysate. Mean of duplicates of a representative experiment are indicated.

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Molecular Cancer

ISSN: 1476-4598