Figure 6
From: Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy
Expression of angiogenic proteins in the treated tumors were analysed using antibody arrays. Density of proteins were plotted and normalised against the positive control Actin. Each group represents the mean (bars, SE) of 8 tumors (i.e. one membrane was used per tumor). Compared to control tumors, VEGF secretion was significantly enhanced in all treatment groups (p < 0.05). In a similar way, compared to control tumors, greater bFGF secretion was noted in all groups (p < 0.05) except long DLI PDT at 24 h. IFN-γ expression was highest at 30 days post long DLI treatment. The inflammatory protein, IL-6 was upregulated in all the treatment groups except long DLI 30 days PDT.