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Table 1 Gene expression profiling was performed using Human Angiogenesis real time PCR Array.

From: Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy

Gene Description

Unigene

Gene Bank

Function

Cadherin 5, type 2, VE-cadherin

Hs.76206

NM_001795

Plays an important role in cell adhesion and is crucial for vessel growth and maturation.

Collagen, type XVIII, alpha 1

Hs.517356

NM_030582

Component of extra-cellular matrix (ECM) that is important for tissue organization.

Collagen, type IV, alpha 3

Hs.570065

NM_000091

 

Integrin, alpha V

Hs.436873

NM_002210

Cell adhesion molecules that plays a key role in tumor growth, angiogenesis and metastasis.

Integrin, beta 3

Hs.218040

NM_000212

 

Hepatocyte growth factor

Hs.396530

NM_000601

Stimulates tumor cell motility, invasion and angiogenesis and its receptor is a tyrosine kinase encoded by c-met.

Ephrin-A3

Hs.516656

NM_004952

Ephrins are cell-membrane-bound ligands for Eph receptor tyrosine kinases and regulate a variety of developmental processes.

Platelet-derived growth factor alpha polypeptide

Hs.645488

NM_002607

Stimulates endothelial cell proliferation.

Epidermal growth factor

Hs.419815

NM_001963

An EGFR ligand, regulates cell growth, proliferation and differentiation.

Neuropilin 2

Hs.471200

NM_003872

Receptor for VEGF and semaphorin (SEMA) and is involved in angiogenesis and neuronal guidance.

Ephrin-B2

Hs.149239

NM_004093

An Eph ligand, promotes cell attachment, cell-adhesion, migration, capillary tube formation and tumor angiogenesis.

Jagged 1

Hs.224012

NM_000214

A notch ligand, it regulates a transmembrane ligand-receptor signaling pathway involved in the regulation of endothelial cell differentiation.

Tumor necrosis factor, alpha-induced protein 2

Hs.525607

NM_006291

A cytokine mainly produced by macrophages causes apoptotic cell death, cellular proliferation, differentiation and inflammation.

TEK tyrosine kinase, endothelial

Hs.89640

NM_000459

Helps in vascular maturation, maintenance of integrity and remodeling.

Transforming growth factor, alpha

Hs.170009

NM_003236

Binds to EGFR and is involved in tumorigenesis.

Vascular endothelial growth factor C

Hs.435215

NM_005429

Involved in angiogenesis and lymphangiogenesis.

  1. Selected genes that are involved in the angiogenesis pathway in HY-PDT treated tumors are listed below. The gene description, unigene entry, gene bank code and the function of each gene are described in the table.