From: Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy
Gene Description | Unigene | Gene Bank | Function |
---|---|---|---|
Cadherin 5, type 2, VE-cadherin | Hs.76206 | NM_001795 | Plays an important role in cell adhesion and is crucial for vessel growth and maturation. |
Collagen, type XVIII, alpha 1 | Hs.517356 | NM_030582 | Component of extra-cellular matrix (ECM) that is important for tissue organization. |
Collagen, type IV, alpha 3 | Hs.570065 | NM_000091 | Â |
Integrin, alpha V | Hs.436873 | NM_002210 | Cell adhesion molecules that plays a key role in tumor growth, angiogenesis and metastasis. |
Integrin, beta 3 | Hs.218040 | NM_000212 | Â |
Hepatocyte growth factor | Hs.396530 | NM_000601 | Stimulates tumor cell motility, invasion and angiogenesis and its receptor is a tyrosine kinase encoded by c-met. |
Ephrin-A3 | Hs.516656 | NM_004952 | Ephrins are cell-membrane-bound ligands for Eph receptor tyrosine kinases and regulate a variety of developmental processes. |
Platelet-derived growth factor alpha polypeptide | Hs.645488 | NM_002607 | Stimulates endothelial cell proliferation. |
Epidermal growth factor | Hs.419815 | NM_001963 | An EGFR ligand, regulates cell growth, proliferation and differentiation. |
Neuropilin 2 | Hs.471200 | NM_003872 | Receptor for VEGF and semaphorin (SEMA) and is involved in angiogenesis and neuronal guidance. |
Ephrin-B2 | Hs.149239 | NM_004093 | An Eph ligand, promotes cell attachment, cell-adhesion, migration, capillary tube formation and tumor angiogenesis. |
Jagged 1 | Hs.224012 | NM_000214 | A notch ligand, it regulates a transmembrane ligand-receptor signaling pathway involved in the regulation of endothelial cell differentiation. |
Tumor necrosis factor, alpha-induced protein 2 | Hs.525607 | NM_006291 | A cytokine mainly produced by macrophages causes apoptotic cell death, cellular proliferation, differentiation and inflammation. |
TEK tyrosine kinase, endothelial | Hs.89640 | NM_000459 | Helps in vascular maturation, maintenance of integrity and remodeling. |
Transforming growth factor, alpha | Hs.170009 | NM_003236 | Binds to EGFR and is involved in tumorigenesis. |
Vascular endothelial growth factor C | Hs.435215 | NM_005429 | Involved in angiogenesis and lymphangiogenesis. |