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Table 2 Gene expression profiling was performed for HY-PDT treated tumors.

From: Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy

Gene

Gene Symbol

Short DLI PDT 24 h

Long DLI PDT 24 h

  

Fold change

p-value

Up(↑)/down (↓) regulation

Fold change

p-value

Up (↑)/down (↓) regulation

Adhesion molecules

       

Cadherin 5, type 2, VE-cadherin

CDH5

0.080

0.015

↓

0.214

0.0313

↓

Collagen, type XVIII, alpha 1

COL18A1

0.016

0.0335

↓

0.024

0.051

↓

Collagen, type IV, alpha 3

COL4A3

0.006

0.0075

↓

0.027

0.027

↓

Integrin, alpha V

ITGAV

0.0007

0.00003

↓

0.086

0.029

↓

Integrin, beta 3

ITGB3

0.169

0.027

↓

0.144

0.025

↓

Growth factors and receptors

       

Hepatocyte growth factor

HGF

30.70

0.00008

↑

8.04

0.0014

↑

Ephrin-A3

EFNA3

12.76

0.026

↑

12.47

0.035

↑

Platelet-derived growth factor alpha polypeptide

PDGFA

10.15

0.038

↑

22.68

0.0109

↑

Epidermal growth factor

EGF

7.013

0.003

↑

0.051

0.017

↓

Neuropilin 2

NRP2

5.502

0.031

↑

5.993

0.012

↑

Ephrin-B2

EFNB2

0.003

0.0002

↓

0.205

0.039

↓

Jagged 1

JAG1

0.001

0.008

↓

0.004

0.021

↓

Tumor necrosis factor, alpha-induced protein 2

TNFAIP2

3.34

0.045

↑

0.136

0.031

↓

TEK tyrosine kinase, endothelial

TEK

0.250

0.042

↓

0.218

0.0028

↓

Transforming growth factor, alpha

TGFA

0.054

0.030

↓

0.018

0.0106

↓

Vascular endothelial growth factor C

VEGFC

0.0031

0.003

↓

0.023

0.013

↓

  1. The gene symbol, fold-change, p-value and the status of transcription have been described for each gene. The genes involved in the angiogenesis pathway were divided into two groups – adhesion molecules and growth factors and receptors. Six genes regulating the angiogenesis pathway i.e., HGF, EFNA3, EGF, NRP2, PDGFA and TNFAIP2 were upregulated in both short and long DLI 24 h HY-PDT with the exception of EGF in long DLI HY-PDT and 10 genes CDH5, COL18A1, COL4A3, EFNB2, ITGAV, ITGB3, TEK, TGFA, VEGFC and JAG1 were downregulated in both short and long 24 h HY-PDT when compared with the controls (p values are given in the table).