From: Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy
Gene | Gene Symbol | Short DLI PDT 24 h | Long DLI PDT 24 h | ||||
---|---|---|---|---|---|---|---|
 |  | Fold change | p-value | Up(↑)/down (↓) regulation | Fold change | p-value | Up (↑)/down (↓) regulation |
Adhesion molecules | Â | Â | Â | Â | Â | Â | Â |
Cadherin 5, type 2, VE-cadherin | CDH5 | 0.080 | 0.015 | ↓ | 0.214 | 0.0313 | ↓ |
Collagen, type XVIII, alpha 1 | COL18A1 | 0.016 | 0.0335 | ↓ | 0.024 | 0.051 | ↓ |
Collagen, type IV, alpha 3 | COL4A3 | 0.006 | 0.0075 | ↓ | 0.027 | 0.027 | ↓ |
Integrin, alpha V | ITGAV | 0.0007 | 0.00003 | ↓ | 0.086 | 0.029 | ↓ |
Integrin, beta 3 | ITGB3 | 0.169 | 0.027 | ↓ | 0.144 | 0.025 | ↓ |
Growth factors and receptors | Â | Â | Â | Â | Â | Â | Â |
Hepatocyte growth factor | HGF | 30.70 | 0.00008 | ↑ | 8.04 | 0.0014 | ↑ |
Ephrin-A3 | EFNA3 | 12.76 | 0.026 | ↑ | 12.47 | 0.035 | ↑ |
Platelet-derived growth factor alpha polypeptide | PDGFA | 10.15 | 0.038 | ↑ | 22.68 | 0.0109 | ↑ |
Epidermal growth factor | EGF | 7.013 | 0.003 | ↑ | 0.051 | 0.017 | ↓ |
Neuropilin 2 | NRP2 | 5.502 | 0.031 | ↑ | 5.993 | 0.012 | ↑ |
Ephrin-B2 | EFNB2 | 0.003 | 0.0002 | ↓ | 0.205 | 0.039 | ↓ |
Jagged 1 | JAG1 | 0.001 | 0.008 | ↓ | 0.004 | 0.021 | ↓ |
Tumor necrosis factor, alpha-induced protein 2 | TNFAIP2 | 3.34 | 0.045 | ↑ | 0.136 | 0.031 | ↓ |
TEK tyrosine kinase, endothelial | TEK | 0.250 | 0.042 | ↓ | 0.218 | 0.0028 | ↓ |
Transforming growth factor, alpha | TGFA | 0.054 | 0.030 | ↓ | 0.018 | 0.0106 | ↓ |
Vascular endothelial growth factor C | VEGFC | 0.0031 | 0.003 | ↓ | 0.023 | 0.013 | ↓ |