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Table 1 Over expressed genes as a consequence of chromosome 5p gain in cervical cancer

From: Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha

Gene

Description

Function

Role in cancer

Average fold change#

OSMR

Oncostatin M receptor

Signal transduction

[31]

3.1

BASP1

Brain abundant, membrane attached signal protein 1

DNA binding

-

6.0

C5orf28

Chromosome 5 open reading frame 28

Not known

-

2.9

TRIP13

Thyroid hormone receptor interactor 13

HPV16 E1 protein binding protein

[24]

5.0

NNT

Nicotinamide nucleotide transhydrogenase

Detoxification of ROS

-

3.7

TARS

Threonyl-tRNA synthetase

Aminoacylation of tRNA

-

3.2

PAIP1

Polyadenylate-binding protein-interacting protein 1

Translation activator activity

-

2.3

SDHA

Succinate dehydrogenase complex, subunit A, flavoprotein

Oxidative phosphorylation

-

3.4

NDUFS6

NADH dehydrogenase (ubiquinone) Fe-S protein 6

Oxidative phosphorylation

-

2.3

BRD9

Bromodomain containing 9

Nucleic acid binding

-

2.2

FASTKD3

FAST kinase domains 3

Unknown

-

2.4

RAD1

RAD1 homolog

DNA repair, cell cycle check point

-

3.2

BXDC2

Brix domain containing 2

Ribosomal biosynthesis

-

2.6

SKP2

S-phase kinase-associated protein 2

Mitotic check point

[33]

3.6

C5orf22

Chromosome 5 open reading frame 22

Unknown

-

3.0

POLS

Polymerase (DNA directed) sigma

DNA repair

-

2.8

RNASEN

Ribonuclease III, nuclear

miRNA processing

[27]

2.8

  1. # Fold-change is calculated based on comparison between normal cervical squamous epithelium and tumors with Chr5p gain