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Table 1 Over expressed genes as a consequence of chromosome 5p gain in cervical cancer

From: Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha

Gene Description Function Role in cancer Average fold change#
OSMR Oncostatin M receptor Signal transduction [31] 3.1
BASP1 Brain abundant, membrane attached signal protein 1 DNA binding - 6.0
C5orf28 Chromosome 5 open reading frame 28 Not known - 2.9
TRIP13 Thyroid hormone receptor interactor 13 HPV16 E1 protein binding protein [24] 5.0
NNT Nicotinamide nucleotide transhydrogenase Detoxification of ROS - 3.7
TARS Threonyl-tRNA synthetase Aminoacylation of tRNA - 3.2
PAIP1 Polyadenylate-binding protein-interacting protein 1 Translation activator activity - 2.3
SDHA Succinate dehydrogenase complex, subunit A, flavoprotein Oxidative phosphorylation - 3.4
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6 Oxidative phosphorylation - 2.3
BRD9 Bromodomain containing 9 Nucleic acid binding - 2.2
FASTKD3 FAST kinase domains 3 Unknown - 2.4
RAD1 RAD1 homolog DNA repair, cell cycle check point - 3.2
BXDC2 Brix domain containing 2 Ribosomal biosynthesis - 2.6
SKP2 S-phase kinase-associated protein 2 Mitotic check point [33] 3.6
C5orf22 Chromosome 5 open reading frame 22 Unknown - 3.0
POLS Polymerase (DNA directed) sigma DNA repair - 2.8
RNASEN Ribonuclease III, nuclear miRNA processing [27] 2.8
  1. # Fold-change is calculated based on comparison between normal cervical squamous epithelium and tumors with Chr5p gain