Skip to main content

Table 3 Putative biological role of the 22 statistically significantly hypermethylated loci

From: Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer

Functional
Categories
Gene
Symbola
Gene Nameb Gene Functionb
Signaling GDNF glial cell derived neurotrophic factor Growth factor
  GP1BB glycoprotein I b, beta polypeptide Platelet membrane receptor
  OPCML opioid binding protein/cell adhesion molecule-like Cell adhesion molecule
  PENK proenkephalin Opioid peptide precursor
  PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 Phoshatase
  SFRP1 secreted frizzled-related protein 1 Wnt Signaling modulator
  SFRP2 secreted frizzled-related protein 2 Wnt signalling modulator
  TNFRSF25 tumor necrosis factor receptor superfamily, member 25 Cell surface receptor
Transcription Factor HOXC9 homeobox C9 Transcription factor
  NEUROD1 neurogenic differentiation 1 Transcription factor
  NEUROG1 neurogenin 1 Transcription factor
  PAX8 paired box gene – 8 Transcription factor
  PITX2 paired-like homeodomain transcription factor 2 Transcription factor
  TFAP2A transcription factor AP 2 alpha Transcription Factor
  TCF21 transcription factor 21 Transcription factor
Metabolism CYP1B1 cytochrome p450 family 1, subfamily B, polypeptide 1 Liver metabolism
  MT1G metallothionein 1G Heavy metal binding
  MTHFR 5,10 methylenetetrahydrofolate reductase (NADPH) Methyl group metabolism
  SLC38A4 solute carrier family 38, member 4 Amino acid transporter
Other ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 Drug efflux pump
  RARRES1 retinoic acid receptor responder 1 Unclear
  WDR33 WD repeat domain 33 Unclear
  1. a Gene symbol is the Human Genome Organization nomenclature. b Gene Name and Function as listed per [63].