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Table 3 Putative biological role of the 22 statistically significantly hypermethylated loci

From: Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer

Functional

Categories

Gene

Symbola

Gene Nameb

Gene Functionb

Signaling

GDNF

glial cell derived neurotrophic factor

Growth factor

 

GP1BB

glycoprotein I b, beta polypeptide

Platelet membrane receptor

 

OPCML

opioid binding protein/cell adhesion molecule-like

Cell adhesion molecule

 

PENK

proenkephalin

Opioid peptide precursor

 

PTPRN2

protein tyrosine phosphatase, receptor type, N polypeptide 2

Phoshatase

 

SFRP1

secreted frizzled-related protein 1

Wnt Signaling modulator

 

SFRP2

secreted frizzled-related protein 2

Wnt signalling modulator

 

TNFRSF25

tumor necrosis factor receptor superfamily, member 25

Cell surface receptor

Transcription Factor

HOXC9

homeobox C9

Transcription factor

 

NEUROD1

neurogenic differentiation 1

Transcription factor

 

NEUROG1

neurogenin 1

Transcription factor

 

PAX8

paired box gene – 8

Transcription factor

 

PITX2

paired-like homeodomain transcription factor 2

Transcription factor

 

TFAP2A

transcription factor AP 2 alpha

Transcription Factor

 

TCF21

transcription factor 21

Transcription factor

Metabolism

CYP1B1

cytochrome p450 family 1, subfamily B, polypeptide 1

Liver metabolism

 

MT1G

metallothionein 1G

Heavy metal binding

 

MTHFR

5,10 methylenetetrahydrofolate reductase (NADPH)

Methyl group metabolism

 

SLC38A4

solute carrier family 38, member 4

Amino acid transporter

Other

ABCB1

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Drug efflux pump

 

RARRES1

retinoic acid receptor responder 1

Unclear

 

WDR33

WD repeat domain 33

Unclear

  1. a Gene symbol is the Human Genome Organization nomenclature. b Gene Name and Function as listed per [63].