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Table 3 Putative biological role of the 22 statistically significantly hypermethylated loci

From: Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer

Gene Nameb Gene Functionb
Signaling GDNF glial cell derived neurotrophic factor Growth factor
  GP1BB glycoprotein I b, beta polypeptide Platelet membrane receptor
  OPCML opioid binding protein/cell adhesion molecule-like Cell adhesion molecule
  PENK proenkephalin Opioid peptide precursor
  PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 Phoshatase
  SFRP1 secreted frizzled-related protein 1 Wnt Signaling modulator
  SFRP2 secreted frizzled-related protein 2 Wnt signalling modulator
  TNFRSF25 tumor necrosis factor receptor superfamily, member 25 Cell surface receptor
Transcription Factor HOXC9 homeobox C9 Transcription factor
  NEUROD1 neurogenic differentiation 1 Transcription factor
  NEUROG1 neurogenin 1 Transcription factor
  PAX8 paired box gene – 8 Transcription factor
  PITX2 paired-like homeodomain transcription factor 2 Transcription factor
  TFAP2A transcription factor AP 2 alpha Transcription Factor
  TCF21 transcription factor 21 Transcription factor
Metabolism CYP1B1 cytochrome p450 family 1, subfamily B, polypeptide 1 Liver metabolism
  MT1G metallothionein 1G Heavy metal binding
  MTHFR 5,10 methylenetetrahydrofolate reductase (NADPH) Methyl group metabolism
  SLC38A4 solute carrier family 38, member 4 Amino acid transporter
Other ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 Drug efflux pump
  RARRES1 retinoic acid receptor responder 1 Unclear
  WDR33 WD repeat domain 33 Unclear
  1. a Gene symbol is the Human Genome Organization nomenclature. b Gene Name and Function as listed per [63].