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Figure 2 | Molecular Cancer

Figure 2

From: Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression

Figure 2

Microarray analysis of patient samples. (A) Hierarchical clustering of gene expression data obtained from purified diagnostic blood (PBd) and bone marrow (BMd) as well as remission BM (BMr) cells from three investigated patients A-C. (Genes used for clustering satisfied the following two criterions; > 0.5 SD/MEAN across samples, and ≥ 100 expression units in ≥ 10% of arrays used.) (B) Overall hierarchical relationship in gene expression patterns between the samples. (C) Q-PCR analysis of normalized expression levels of VEGF in BMd and PBd in 4 patients (A, C-E). The data presented is triplicates from one representative out of two experiments. Error bars indicate standard deviation. (D) Q-PCR analysis of normalized expression levels of VEGF in BM and PB in 3 patients diagnosed with other disease than ALL. Mb Gauchers (MbG), Post Infection (PI) or Vasculitis (VA) as indicated. The data presented is triplicates and error bars indicate standard deviation.

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Molecular Cancer

ISSN: 1476-4598