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Table 1 Clonal involvement of sorted IgL+ and IgL- cells.

From: Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression

Patient

Translocation

%CD19+ cells

of all BM MNCs

%IgL+ cells of

all CD19+ cells

Population

% FISH+

A

dic(7;12)(p11;p11)

76

15

CD19+IgL-

99

    

CD19+IgL+

1,9

B

t(12;21)(p13;q22)

63

12

CD19+IgL-

99

    

CD19+IgL+

2,7

C

t(1;19)(q23;p13)

84

7

CD19+IgL-

98

    

CD19+IgL+

27

D

High

hyperdiploidy

87

7

CD19+IgL-

99

    

CD19+IgL+

25

E

t(12;21)(p13;q22)

91

2

CD19+IgL-

100

    

CD19+IgL+

3

Patient

WBC ×10 9 /l

%CD19 + cells

of all PB MNCs

%IgL + cells of

all CD19 + cells

Population

% FISH +

A

3.5

54

52

CD19+IgL-

97

    

CD19+IgL+

4,2

B

2.1

9,2

90

CD19+IgL-

ND

    

CD19+IgL+

ND

C

70

57

20

CD19+IgL-

96

    

CD19+IgL+

33

D

23

81

12

CD19+IgL-

99

    

CD19+IgL+

17

E

29

82

5

CD19+IgL-

100

    

CD19+IgL+

8

  1. MNCs from five patients (A-E) analyzed for phenotype by FACS and clonal involvement in IgL+ and IgL- cells by detection of the corresponding chromosome abnormality by FISH. Upper panel shows data from BM at diagnosis and lower panel from PB at diagnosis.