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Figure 3 | Molecular Cancer

Figure 3

From: Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK

Figure 3

Inhibition of nuclear EGFR transport and phosphorylation of DNA-PK by src inhibitor PP2. Confluent A549 cells were treated with src inhibitor PP2 at a concentration of 100 nM for 1 h. Subsequently cells were irradiated with 4 Gy and nuclear proteins were isolated at the time points given. Proteins were separated by SDS-PAGE and after blotting protein amounts were quantified by help of specific antibodies. Expression of specific proteins was quantified by densitometry, normalized to lamin B1 and shown as fold-induction relative to untreated control. Experiments were performed three times; shown are representative results.

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