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Figure 2 | Molecular Cancer

Figure 2

From: Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells

Figure 2

Mean HDACi IC50 values of mock treated or HDAC deprived HeLa cells. HDAC1 KD significantly increases the resistance to belinostat on average 1.9-fold (p < 0.01, n = 10), which is not observed for HDAC2 or -3 KD cells. For VPA, no significance was obtained for the 1.4-fold-changes seen in response to both HDAC1 and -3 KD (n = 5). For all figures, standard errors of the mean IC50 value for each condition are shown. The chemical structures for belinostat and VPA are shown over the graphs.

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Molecular Cancer

ISSN: 1476-4598