Figure 4
From: Metabolite profiling of human colon carcinoma – deregulation of TCA cycle and amino acid turnover
Evaluation of the influence of normalization. Raw (unnormalized) data was used for comparison of differential metabolites between normal colon and colon carcinoma. Of the 24 highly significant metabolites 14 (58%) could be confirmed at the high (p < 0.00024, **) and 19 (79%) at the normal (p < 0.05, *) significance level, indicating that the major metabolite differences are not dependent on the normalization strategy.