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Table 1 Summary of c-Myb mutants.

From: A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding

       % Reporter Activity  
  Repeat-substitutions Missing salt bridges DNA-binding Nuclear Stability c-Myb c-MybVP c-MybΔ Endogenous target gene activation
Wt   0 +++ ++ + 100 100 100 ++
R1 1-1 AEDA 0 +++ ++ + 220 120 168 nd
R1 1–2 AEAA 1 +++ ++ + 45 100 120 +
R1 1–3 AADA 1 +++ ++ + 98 77 83 +
R1 1–4 AAAA 2 + ++ + 10 20 47 +/-
R2 2-1 AED 0 +++ ++ + 94 74 nd nd
R2 2-2 AEA 1 -- +/- + > 1 > 1 nd nd
R2 2–3 AAA 2 -- - +/- > 1 > 1 nd -
R3 3-1 EAEA 0 +++ ++ + 25 100 33 -
R3 3-2 EAAA 1 -- ++ +/- > 1 > 1 nd -
R3 3-3 AAEA 0 +++ ++ + 10 98 19 -
  1. nd = not done.