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Figure 6 | Molecular Cancer

Figure 6

From: Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival

Figure 6

Inhibition of Stat3 pathway by dnStat3 down-regulates survival genes and cyclin-D1 gene. The protein expression levels are shown in (A) UMUC-3 at 27 hours and (B) WH at 48 hours post-infection with rAd/dnStat3 or the control vector, rAd/eGFP as well as in (C) UMUC-3 and (D) WH that are treated with designated concentrations of STA-21 for 4 days. Protein expressions of survival genes (Bcl-xL, Bcl-2, Mcl-1 and survivin) and cyclin-D1 were subject to densitometric quantification and shown in percents of the untreated controls after being normalized to the GAPDH expression. A representative experiment of triplicates is shown.

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