Figure 9
An integrative model for recurrence in ovarian cancer. Schematic representation of putative genes and gene families involved in the recurrence of ovarian carcinomas. According to our current working concept, tumour cells during relapse produce adhesion molecules to mediate attachment and invasion via co-overexpression of matrix metalloproteinases, cytokines and inflammatory mediators to stimulate survival and a variety of growth factors bound to their cognate receptors to fully proliferate in order to confront and modulate their immediate environment, which they must eventually overtake.