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Figure 4 | Molecular Cancer

Figure 4

From: Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer

Figure 4

Correlation of SFRP2 promoter methylation and loss of SFRP2 mRNA expression in breast cell lines. (A) Realtime PCR of eight breast cell lines revealed abundant SFRP2 mRNA expression in benign HMEC and malignant Hs578T cells (green bars), whereas in all other investigated malignant breast cell lines SFRP2 mRNA expression was substantially reduced (grey bars). (B) Plotting of SFRP2 mRNA expression from the same cell lines (Y-axis) against each mean SFRP2 promoter methylation value (X-axis) reveals a significant correlation between loss of RNA expression and SFRP2 promoter methylation (P = 0.001; Pearson's correlation coefficient r = -0.9241).

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Molecular Cancer

ISSN: 1476-4598