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Figure 5 | Molecular Cancer

Figure 5

From: Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer

Figure 5

SFRP2 protein expression in normal and malignant breast tissues. (A) In the negative control showing normal breast tissue the primary SFRP2 antibody was omitted. (B) Scale-up of negative control shown in A. (C) Strong SFRP2 expression in ducts and lobules of normal breast tissue (IRS = 12). SFRP2 expression is abundant in epithelial cells, while there is only weak expression in stromal cells. (D) Very abundant SFRP2 expression in ductal carcinoma in situ of the breast. (E) Scale-up of specimen shown in D. (F) High-grade tumor exhibiting substantial loss of SFRP2 expression (IRS = 0). (G) Scale-up of specimen shown in F. (H) High-grade breast carcinoma with intensive cytoplasmic SFRP2 staining (IRS = 12). Original magnifications: A, F = 100×; B, C, G, H = 200×; D = 40×; E = 400×.

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