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Figure 4 | Molecular Cancer

Figure 4

From: Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells

Figure 4

Testosterone-BSA induces activation of the pro-apoptotic Bad protein in DU145 cells. DU145 cells were exposed for different time periods (A: 0, 1, 2, 6) and (B: 12 and 24 h) to 10-7 M testosterone-BSA (testo-BSA). The ratio of the cellular content of the phosphorylated versus the total form of Bad was determined in cell lysates by Western blotting using specific antibodies. Blots show a representative experiment, while results are presented as the mean values ± SE from three independent experiments normalized versus the corresponding short- and long-term untreated controls respectively (**P < 0.01).

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Molecular Cancer

ISSN: 1476-4598