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Figure 7 | Molecular Cancer

Figure 7

From: Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells

Figure 7

Testosterone-BSA-induced apoptosis is inhibited in the presence of a specific Fas blocking peptide. FACS analysis of DU145 cells treated with 10-7 M testosterone-BSA (serum conditions), 10 ÎĽM of Fas blocking peptide (in serum free conditions) and both of these in parallel (serum conditions). Cells cultured in serum or 24 h serum starved cells were used as a negative and positive control for apoptosis respectively. Cells were co-stained with Annexin V-FITC for apoptotic cells and the vitality marker propidium iodide (PI). Representative percentages of viable and apoptotic cells under each condition are presented in the table.

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Molecular Cancer

ISSN: 1476-4598