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Figure 4 | Molecular Cancer

Figure 4

From: Down-regulation of PPARgamma1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells

Figure 4

Down-regulation of PPARγ1 or expression of MAZ prevents S-phase entry in MCF-7 breast cancer cells. Changes in cell cycle distribution of MCF-7 cells transfected with or without scrambled, MAZ, or PPARγ1 shRNA were analyzed by FACS. Cells were stained with propidium iodide (PI). Mean and s.e.m. from five independent experiments are shown. Error bars that do not share a letter designation were determined to be significantly different by Fisher's LSD pairwise comparison (p < 0.05). A. Inhibition of PPARγ1 or MAZ expression leads to a decrease in a number of cells entering S-phase. B. A decrease in the number of proliferating cells in PPARγ1 or MAZ shRNA transfected cells is associated with an increase in the number of G0-G1 arrested cells. C. There was no significant difference in M-G2 phase cell number observed among all groups. D. Down-regulation of PPARγ1 as well as MAZ leads to an increase in the number of apoptotic cells.

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