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Figure 3 | Molecular Cancer

Figure 3

From: Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability

Figure 3

Pin1 depletion sensitizes erbB2-amplified cells to Rapamycin but not to Trastuzumab treatments. SKBR3 cells (A, D), BT474 cells (B, E) and AU565 cells (C, F) were transfected with control RNAi (dark symbols) or Pin1 siRNA (open symbols), and seeded on day 3 after transfection at 5000 cells/well in 96-well plates, and treated with the indicated concentrations of Rapamycin or Trastuzumab. Cells were allowed to grow for 5 days and the resulting cultures were subjected to an MTT-based viability assay and read in a 96 well reader. Assays were done in triplicates.

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Molecular Cancer

ISSN: 1476-4598