Figure 5

LMO4 expressions in the PanIN-IDC pathway, including 13 normal ductal epithelial ducts, 14 PanIN-1B lesions, 3 PanIN-2 lesions, and 8 IDC lesions. IDC cells (mean, 2.19; 95% CI, 1.43 – 2.94) expressed significantly higher levels of LMO4 than did normal ductal epithelia (mean, 0.45; 95% CI, 0.30 – 0.60), PanIN-1B (mean, 0.41; 95% CI, 0.27 – 0.54), or PanIN-2 cells (mean, 0.32; 95%CI 0.18 – 0.45). The differences in LMO4 expression among PanIN-2, PanIN-1B, and normal ductal epithelial cells are not statistically significant (p = 0.54 and p = 0.56). The bottom and the top edges of the box mark the lower bound and upper bound of the 95% Confidence Interval for the Mean, respectively. The center horizontal line is drawn at the sample mean. The center vertical lines drawn from the boxes extend to the minimum and the maximum. Expression of LMO4 mRNA was normalized to that of 18S rRNA.