Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines

Table 2 Summary of structural characteristics of MOLM-13

Structural characteristics:	control	khat	CPT
Normal mitochondria	+ + +	+	+ +(+)
Presence of ER	+ + +	+ +	+ +
Ribosomal clustering	-	+	+
Presence of microvilli	+ + +	+	+
Cytosolic vacuolization*	+	+ + +	+ +
Nuclear margination*	-	+++	-
Nuclear fragmentation*	-	+	+ + +

* scores based on khat/CPT treated cells in late phases of cell death
Based on TEM pictures different structural characteristics of MOLM-13 cells following khat (200 μg/ml) and CPT (0.1 μM) treatment were compared to controls and scored (n = 60).

ISSN: 1476-4598