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Table 1 Summary of studies focusing on miRNA expression profiling in colorectal cancer

From: MicroRNAs in colorectal cancer: translation of molecular biology into clinical application

Study Design Tumors (n) Normal1 (n) Cell lines (n) miR examined (n) Technology miR deregulated in tumors2
Michael et al. (53) tumor vs. normal 14 4 2 28 Cloning miR-143, miR-145, miR-21
Bandres et al. (54) tumor vs. normal, TNM staging correlation 12 12 15 156 Real-time PCR miR-31, miR-96, miR-133b, miR-135b, miR-145, miR-183
Cummins et al. (55) miRNAs identification 4 2 5 x miRAGE 133 novel microRNAs
Volinia et al. (56) tumor vs. normal 46 8 0 245 miRNA microarray miR-24-1, miR-29b-2, miR-20a, miR-10a, miR-32, miR-203, miR-106a, miR-17-5p, miR-30c, miR-223, miR-126, miR-128b, miR-21, miR-24-2, miR-99b prec, miR-155, miR-213, miR-150, miR-107, miR-191, miR-221, miR-9-3
Xi et al. (62) tumor vs. normal, correlation with survival, p53 mutation status 24 24 0 10 Real-time PCR miR-15b, miR-181b, miR-191, miR-200c
Lanza et al. (58) MSS tumors vs. MSI tumors 23 MSS 16 MSI 0 0 230 miRNA microarray comparison with colon epithelium was not analyzed
Slaby et al. (22) tumor vs. normal, clinicopathological parameters correlation 29 6 0 5 Real-time PCR miR-143, miR-145, miR-21, miR-31
Nakajima et al. (66) tumor vs. normal, chemoresponse to S-1 21 21 0 5 Real-time PCR let-7g, miR-181b, miR-200c
Monzo et al. (59) tumor vs. normal and embryonic colon 22 22 0 156 Real-time PCR Stage I (n = 28; miR-106a, miR-125b, miR-145, miR-17-5p, miR-200c, miR-21, miR-34a), Stage II (n = 64; miR-106a, miR-128a, miR-15a, miR-15b, miR-17-5p, miR-181a-c, let-7g, miR-200a-c, miR-21, miR-31, miR-34a, miR-92) selection
Schetter et al. (23) tumor vs. normal, correlation with survival, TNM staging 84 (113)3 84 (113)3 0 389 miRNA microarray miR-20a, miR-21, miR-106a, miR-181b, miR-203
Schepeler et al. (65) tumor vs. normal, correlation with recurrence, MSS vs. MSI 49 19 0 315 miRNA microarray miR-145, miR-455, miR-484, miR-101, miR-30b, miR-26b, miR-20a, miR-510, miR-92, miR-513, miR-526c, miR-320, miR-527, miR-432, miR-492, miR-200a, miR-191, miR-302a, miR-512-5p
Motoyama et al. (57) tumor vs. normal, correlation with survival 4 (69)3 4 (69)3 0 455 miRNA microarray miR-31, miR-183, miR-17-5p, miR-18a, miR-20a, miR-92, miR-143, miR-145
Ng et al. (50) tumor, plasma vs. control 5 (25)3 5; (20)3 0 96 Real-time PCR miR-18a, miR-223, miR-224, miR-135b, miR-95, miR-106a, miR-19a+b, miR-17-3p, miR-20a, miR-92, miR-221, miR-106b, miR-222, etc.; markers upregulated in both plasma and tumors are given in bold type
  1. 1Normal colon epithelium, 2only microRNAs deregulated in CRC in comparison to normal colon epithelium are mentioned, 3numbers of patients in the validation cohorts.