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Table 1 Summary of studies focusing on miRNA expression profiling in colorectal cancer

From: MicroRNAs in colorectal cancer: translation of molecular biology into clinical application

Study

Design

Tumors (n)

Normal1 (n)

Cell lines (n)

miR examined (n)

Technology

miR deregulated in tumors2

Michael et al. (53)

tumor vs. normal

14

4

2

28

Cloning

miR-143, miR-145, miR-21

Bandres et al. (54)

tumor vs. normal, TNM staging correlation

12

12

15

156

Real-time PCR

miR-31, miR-96, miR-133b, miR-135b, miR-145, miR-183

Cummins et al. (55)

miRNAs identification

4

2

5

x

miRAGE

133 novel microRNAs

Volinia et al. (56)

tumor vs. normal

46

8

0

245

miRNA microarray

miR-24-1, miR-29b-2, miR-20a, miR-10a, miR-32, miR-203, miR-106a, miR-17-5p, miR-30c, miR-223, miR-126, miR-128b, miR-21, miR-24-2, miR-99b prec, miR-155, miR-213, miR-150, miR-107, miR-191, miR-221, miR-9-3

Xi et al. (62)

tumor vs. normal, correlation with survival, p53 mutation status

24

24

0

10

Real-time PCR

miR-15b, miR-181b, miR-191, miR-200c

Lanza et al. (58)

MSS tumors vs. MSI tumors

23 MSS 16 MSI

0

0

230

miRNA microarray

comparison with colon epithelium was not analyzed

Slaby et al. (22)

tumor vs. normal, clinicopathological parameters correlation

29

6

0

5

Real-time PCR

miR-143, miR-145, miR-21, miR-31

Nakajima et al. (66)

tumor vs. normal, chemoresponse to S-1

21

21

0

5

Real-time PCR

let-7g, miR-181b, miR-200c

Monzo et al. (59)

tumor vs. normal and embryonic colon

22

22

0

156

Real-time PCR

Stage I (n = 28; miR-106a, miR-125b, miR-145, miR-17-5p, miR-200c, miR-21, miR-34a), Stage II (n = 64; miR-106a, miR-128a, miR-15a, miR-15b, miR-17-5p, miR-181a-c, let-7g, miR-200a-c, miR-21, miR-31, miR-34a, miR-92) selection

Schetter et al. (23)

tumor vs. normal, correlation with survival, TNM staging

84 (113)3

84 (113)3

0

389

miRNA microarray

miR-20a, miR-21, miR-106a, miR-181b, miR-203

Schepeler et al. (65)

tumor vs. normal, correlation with recurrence, MSS vs. MSI

49

19

0

315

miRNA microarray

miR-145, miR-455, miR-484, miR-101, miR-30b, miR-26b, miR-20a, miR-510, miR-92, miR-513, miR-526c, miR-320, miR-527, miR-432, miR-492, miR-200a, miR-191, miR-302a, miR-512-5p

Motoyama et al. (57)

tumor vs. normal, correlation with survival

4 (69)3

4 (69)3

0

455

miRNA microarray

miR-31, miR-183, miR-17-5p, miR-18a, miR-20a, miR-92, miR-143, miR-145

Ng et al. (50)

tumor, plasma vs. control

5 (25)3

5; (20)3

0

96

Real-time PCR

miR-18a, miR-223, miR-224, miR-135b, miR-95, miR-106a, miR-19a+b, miR-17-3p, miR-20a, miR-92, miR-221, miR-106b, miR-222, etc.; markers upregulated in both plasma and tumors are given in bold type

  1. 1Normal colon epithelium, 2only microRNAs deregulated in CRC in comparison to normal colon epithelium are mentioned, 3numbers of patients in the validation cohorts.