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Table 2 Representative gene expression changes decreased in BALBLsp-d compared to BALB mice.

From: Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesis

B.

Gene Symbol*

Gene Name

Affymetrix Probe ID

Major GO Category(ies)

Cell cycle and cell growth

Csf1r

colony stimulating factor 1 receptor

1419872_at

regulation of progression through cell cycle; protein amino acid phosphorylation

Fgf7 †

fibroblast growth factor 7

1422243_at

regulation of progression through cell cycle;; signal transduction

Gas6

growth arrest specific 6

1417399_at

regulation of cell growth

Htra1

htrA serine peptidase 1

1416749_at

regulation of cell growth; proteolysis

Itm2b

integral membrane protein 2B

1418000_a_at

apoptosis

Cell shape and morphogenesis

Itga8 †

integrin alpha 8

1427489_at

cell adhesion

Nox4 †

NADPH oxidase 4

1419161_a_at

cell morphogenesis; electron transport

Pik3r1 †

phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)

1425515_at

negative regulation of cell-matrix adhesion; protein amino acid phosphorylation

Postn

periostin, osteoblast specific factor

1423606_at

cell adhesion

Protein targeting

Arl6ip1

ADP-ribosylation factor-like 6 interacting protein 1

1451131_at

cotranslational protein targeting to membrane

Tmod1

tropomodulin 1

1422754_at

myofibril assembly; muscle thick filament assembly

Transcription, processing, and chromatin structure

Hp1 bp3

heterochromatin protein 1, binding protein 3

1415751_at

nucleosome assembly

Klf15

Kruppel-like factor 15

1448181_at

regulation of transcription, DNA-dependent

Rora †

RAR-related orphan receptor alpha

1420583_a_at

regulation of transcription, DNA-dependent

Slu7

SLU7 splicing factor homolog

1420030_at

alternative nuclear mRNA splicing, via spliceosome

  1. * These genes were identified after bioinformatic analysis filtering first on biological patterns using both Genespring and Spotfire Software followed by filtering on GO biological categories using the DAVID Bioinformatics Database. †These genes were down-regulated ≥ 2-fold in BALBLsp-dvs. BALB 1 day following protocol 1 (chronic BHT) (P < 0.05)