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Figure 6 | Molecular Cancer

Figure 6

From: Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis

Figure 6

CD31 immunohistochemistry assay displayed that overexpression of RRM2 resulted in more vascularized tumor xenografts. Representative immunohistochemical assay of vascularization of tumor xenografts generated in vivo by (A) KB-V and (B) KB-M2-D cells (×100). (C) Semi-quantitative analysis showed that CD31 staining was significantly increased in KB-M2D tumor xenografts compared with that of KB-V, *p < 0.05. Values expressed were the mean ± SD of 8 mice of two independent experiments.

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