Figure 6From: Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesisCD31 immunohistochemistry assay displayed that overexpression of RRM2 resulted in more vascularized tumor xenografts. Representative immunohistochemical assay of vascularization of tumor xenografts generated in vivo by (A) KB-V and (B) KB-M2-D cells (×100). (C) Semi-quantitative analysis showed that CD31 staining was significantly increased in KB-M2D tumor xenografts compared with that of KB-V, *p < 0.05. Values expressed were the mean ± SD of 8 mice of two independent experiments.Back to article page