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Table 1 Characteristics of OS case series.

From: Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways

Case Gender Histology Grade Site BRAF mutations P-ERK1/2 * MCL-1 * P-ERM *
1 M OSTEOBLASTIC G4 TIBIA - - + +
2 M OSTEOBLASTIC G4 FEMUR - - + -
3 F OSTEOBLASTIC G4 FEMUR - - - -
4 M OSTEOBLASTIC G4 TIBIA - - - +
5 M OSTEOBLASTIC G4 HOMER 596 delA - - -
6 F OSTEOBLASTIC G4 TIBIA - - + -
7 F OSTEOBLASTIC G4 FEMUR - - + +
8 M OSTEOBLASTIC G4 FEMUR - - ++ +
9 M OSTEOBLASTIC G4 TIBIA - - + +
10 M OSTEOBLASTIC G4 FEMUR - - + +
11 M OSTEOBLASTIC G4 FEMUR - ++ ++ +
12 F OSTEOBLASTIC G4 FEMUR - + - -
13 M OSTEOBLASTIC G4 FEMUR H608L ++ ++ +
14 M OSTEOBLASTIC G4 FEMUR - + + -
15 M OSTEOBLASTIC G4 HOMER - ++ ++ +
16 M OSTEOBLASTIC G4 TIBIA - ++ + +
17 F OSTEOBLASTIC G4 FEMUR - + + +
18 M OSTEOBLASTIC G4 FEMUR - + ++ -
19 F OSTEOBLASTIC G4 HOMER - ++ + ++
20 M OSTEOBLASTIC G4 TIBIA - + + +
21 M OSTEOBLASTIC G4 FEMUR - ++ ++ +
22 M OSTEOBLASTIC G4 FEMUR G615R ++ ++ ++
23 M FIBROBLASTIC G4 TIBIA - + ++ -
24 M FIBROBLASTIC G4 FEMUR - ++ - +
25 M OSTEOBLASTIC G4 FEMUR - + + -
26 F OSTEOBLASTIC G3 HOMER - + - +
27 M OSTEOBLASTIC G4 FEMUR - + + ++
28 M OSTEOBLASTIC G4 FEMUR S602Y + + +
29 F OSTEOBLASTIC G4 HOMER - + ++ +
30 M OSTEOBLASTIC G4 TIBIA - ++ ++ ++
  1. Gender, histological subtypes, grading, site of tumor origin, immunohistochemical results of P-ERK1/2, MCL- 1 and P-ERM expression and BRAF exon 15 mutations of each osteosarcoma samples from patients. intensity of expression: (-)< 10% positive cells scored -, 10-50% positive cells scored +;> 50% positive cells and high staining intensity scored ++).
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Molecular Cancer

ISSN: 1476-4598