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Table 2 Concentrations of sorafenib inhibiting 50% of OS cell line proliferation.

From: Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways

Cell line IC50 (μM) Confidence Intervals (μM)
MG63 2.793 2.32-3.35
U2OS 4.677 2.99-6.61
SAOS-2 3.943 1.87-5.31
KHOS 2.417 1.88-3.10
HOS 4.784 3.99-5.48
SJSA-1 4.511 3.01-6.71
MNNG-HOS 4.814 3.13-6.39
  1. IC50 values (μM) and relative 95% confidence intervals obtained after 72 hours of sorafenib exposure.* IC50: Sorafenib concentration inhibiting 50% of the cell line proliferation.