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Table 2 Concentrations of sorafenib inhibiting 50% of OS cell line proliferation.

From: Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways

Cell line

IC50 (μM)

Confidence Intervals (μM)

MG63

2.793

2.32-3.35

U2OS

4.677

2.99-6.61

SAOS-2

3.943

1.87-5.31

KHOS

2.417

1.88-3.10

HOS

4.784

3.99-5.48

SJSA-1

4.511

3.01-6.71

MNNG-HOS

4.814

3.13-6.39

  1. IC50 values (μM) and relative 95% confidence intervals obtained after 72 hours of sorafenib exposure.* IC50: Sorafenib concentration inhibiting 50% of the cell line proliferation.
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Molecular Cancer

ISSN: 1476-4598