Table 1 Tumor expressions of IGFBP-3, p53 and IGFBP-3 promoter methylation and the clinicopathological features in patients with OEC.
From: Promoter methylation of IGFBP-3 and p53 expression in ovarian endometrioid carcinoma
Characteristics | IGFBP-3 | p53 | IGFBP-3 Methylation | ||||||
|---|---|---|---|---|---|---|---|---|---|
High N = 36 | Low N = 24 | p value | Normal N = 39 | Overexpression N = 21 | p- value | ≤ 3% N = 20 | > 3% N = 20 | p value | |
Age (mean ± SD) | 51.7 ± 11.9 | 52.2 ± 12.7 | 0.88 | 49.3 ± 12.3 | 55.7 ± 11.7 | 0.06 | 51.8 ± 12.9 | 51.5 ± 13.3 | 0.94 |
Stage | |||||||||
I | 22 | 6 | 20 | 8 | 11 | 8 | |||
II | 5 | 2 | 0.02 | 5 | 2 | 0.54 | 4 | 1 | 0.24 |
III | 9 | 15 | 14 | 10 | 5 | 10 | |||
IV | 0 | 1 | 0 | 1 | 0 | 1 | |||
Grade | |||||||||
1 | 19 | 0 | 16 | 3 | 11 | 4 | |||
2 | 11 | 12 | < 0.001 | 12 | 11 | 0.09 | 5 | 9 | 0.05 |
3 | 6 | 11 | 11 | 6 | 3 | 7 | |||
Low IGFBP-3 | 17 (43.6%) | 7 (33.3%) | 0.77 | 2 (10.0%) | 12 (60.0%) | 0.003 | |||
p53 overexpression | 14 (38.9%) | 7 (29.2%) | 0.62 | 8 (12.5%) | 6 (30.0%) | 0.11 | |||