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Table 1 Methylation in the CpG island encompassing the PTPRR isoform 1 start site in colorectal tumors.

From: The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis

Tumor type1

No.

Methylated (%)2

Unmethylated (%)

Premalignant lesions

   

   Polypoid

28

23 (82)

5 (18)

   Nonpolypoid

18

15 (83)

3 (17)

Primary adenocarcinomas

44

42 (95)

2 (5)

Liver metastases 3

8

8 (100)

0 (0)

  1. 1The normal mucosa counterpart was also analyzed for 21 samples (see Results)
  2. 2Positivity threshold: ≥ 5% alleles (see Methods)
  3. 3Associated with 8 of the 44 primary cancers listed above