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Figure 11 | Molecular Cancer

Figure 11

From: Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines

Figure 11

Effects of PF-228 on the phosphorylation of FAK, Akt and ERK in pancreatic cancer cells. A, Panc-1 cells were treated with or without the indicated concentrations of PF-228 for 1 h. B, After pretreated with or without the indicated concentrations of PF-228 for 30 min in serum-free medium, suspended AsPC-1 cells were plated onto plastic or LN-coated plates for 1 h in the continued presence or absence of PF-228. Western blot showed expression of pFAK (pY397), p-Akt (pS473), p-ERK 1/2 and their total proteins in the cells. The membranes were probed with anti-β-actin antibody to ensure even loading of proteins in each lane.

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Molecular Cancer

ISSN: 1476-4598