Molecular Cancer

Table 1 Statistical evaluation of the results concerning the effects of ABCA1 on response to Curcumin

From: Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells

p65
Bonferroni's Multiple Comparison Test	Mean Diff.	t	P value	95% CI of diff
435nonsi vs 435nonsi Cur	1,393	0,2931	P > 0.05	-11.03 to 13.81
435nonsi vs 435ABCA1si	12,22	2,57	P > 0.05	-0.2006 to 24.64
435nonsi vs 435ABCA1si Cur	18,4	3,872	P < 0.01	5.985 to 30.82
bcl2
Bonferroni's Multiple Comparison Test	Mean Diff.	t	P value	95% CI of diff
M14nonsi vs M14nonsi Cur	-0,00009025	0,4383	P > 0.05	-0.0006282 to 0.0004477
M14nonsi vs M14ABCA1si	0,0004488	2,18	P > 0.05	-0.00008914 to 0.0009868
M14nonsi vs M14ABCA1si Cur	0,0009655	4,689	P < 0.001	0.0004275 to 0.001503
Survivin
Bonferroni's Multiple Comparison Test	Mean Diff.	t	P value	95% CI of diff
M14nonsi vs M14nonsi Cur	-0,00006799	0,1184	P > 0.05	-0.001568 to 0.001432
M14nonsi vs M14ABCA1si	0,001349	2,349	P > 0.05	-0.0001513 to 0.002849
M14nonsi vs M14ABCA1si Cur	0,002271	3,955	P < 0.01	0.0007706 to 0.003770
Apoptose
Bonferroni's Multiple Comparison Test	Mean Diff.	t	P value	95% CI of diff
M14nonsi vs M14nonsi Cur	0,000869	0,005529	P > 0.05	-0.4193 to 0.4210
M14nonsi vs M14ABCA1si	-0,07965	0,5067	P > 0.05	-0.4998 to 0.3405
M14nonsi vs M14ABCA1si Cur	-0,688	4,377	P < 0.01	-1.108 to -0.2679

Knocking-down the multidrug resistance gene alone already inhibits expression of the NFκB subunit p65 and the survival factors bcl2 and survivin and induces apoptosis in melanoma cells. However these effects are not statistically significant. Only the combination of knocking down ABCA1 together with simultaneous application of Curcumin results in a statistically highly significant response in terms of apoptosis.

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ISSN: 1476-4598

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