Figure 5
From: Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients
Increased phosphoryaltion of S6K in kidney tumors. (A) Immunoblot and (B) immunostaining analysis of phopho-S6K (Thr-389) and total S6K in normal kidney samples and kidney tumor from patients with tuberous sclerosis. Phosphorylation of S6K was significantly higher in tumor kidney tissue compared to normal kidney confirming the increase of mTOR activity. Tubulin was used as loading control. Histograms represent means ± SE normal kidney samples and kidney tumors from patients with tuberous sclerosis. Significant difference between control and tumor groups is indicated by **P < 0.01.