Figure 7
From: Anomalous constitutive Src kinase activity promotes B lymphoma survival and growth
Dasatinib inhibits B lymphoma growth in vivo. Dasatinib significantly reduced the splenic B lymphoma burden in CBA/N (Xid) mice. Female CBA/N (Xid) mice were injected intravenously with 7 × 106 BKS-2 B lymphoma cells on day 0. From day 1, mice were injected intraperitoneally either with drug (dasatinib) or vehicle (1 × PBS, 10% DMSO) everyday for 14 days. (A) A comparison of the spleen sizes between drug and vehicle treated lymphoma bearing mice. (B) The average counts of total splenic cells between drug and vehicle treated lymphoma bearing mice.