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Figure 5 | Molecular Cancer

Figure 5

From: Evaluation of bioluminescent imaging for noninvasive monitoring of colorectal cancer progression in the liver and its response to immunogene therapy

Figure 5

Analysis of luciferase stability and function in vivo. A. – Intrahepatic MC38Luc1 tumors (n = 10) were excised at different times after cell implantation (2, 3 and 4 weeks), and the relative copy number of the plasmid pCDNA3-luc was determined by qPCR. The values correspond to the number of plasmid copies divided by the copies of the endogenous albumin gene. Error bars represent standard deviations. B. – Correlation between the relative pCDNA3-luc copy number in advanced tumors (4 weeks after implantation) and tumor volume. C. – Correlation between in vivo light emission of advanced tumors (in photons/sec.) and luciferase activity (in RLUs) obtained in solution from tumor extracts (log10 conversion of values).

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Molecular Cancer

ISSN: 1476-4598