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Figure 1 | Molecular Cancer

Figure 1

From: Identification of novel Cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo

Figure 1

Administration of the specific Cox-2 inhibitor NS398 does not significantly affect bacterial colonization or inflammatory scores. A. Treatment with NS398 does not influence H. pylori colonization in C57 BL/6 mice. CFU retrieved from the stomachs of individual mice at 6, 13 and 19 weeks post infection (filled circles). B. Distribution of pathology scores in infected and control mice. Pathology was scored according to the Sydney system as follows: no inflammation (0), low grade, non -active gastritis and low grade mild-active gastritis (1), middle grade mild active gastritis (2). C. Hematoxylin and Eosin stained paraffin sections from 13 weeks post infection, representative images from non-infected mice treated with vehicle only (V), non infected mice treated with NS398 (NS398), infected mice (V+Hp), and infected mice treated with NS398 (NS398+Hp). By week 13 (17 weeks post-infection), moderate active gastritis was observed in both the V+Hp and NS398+Hp groups. Original magnification 20×, scale bar = 50 μm.

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