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Figure 2 | Molecular Cancer

Figure 2

From: Identification of novel Cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo

Figure 2

Global gene expression in the gastric mucosa of mice infected with H. pylori. A. Venn diagram illustrating the breakdown of differentially expressed genes (more than 3 fold up or down) over the period of the study. The number of genes passing the cut-off criteria is indicated for each experimental comparison: Infected versus non-infected mice (V vs V+Hp), infected mice versus NS398 treated and infected mice (V+Hp vs NS398+Hp), and non-infected mice versus NS398 treated (V vs NS398). Numbers in parentheses represent the number total genes differently expressed in the three experimental comparisons. B. Trend plots representing global gene expression measured in the 3 experimental comparisons. Each point on the y-axes represents the average expression ratio for genes passing the cut-off criteria at weeks 6, 13 and 19 after treatment starts, i.e. one line represents one gene. The 33 infection-related genes that were differently expressed as a result of NS398 treatment are highlighted in red for all comparisons. Cox-2 (Ptgs2) is indicated by the yellow line.

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