Table 3 Function of selected Cox-2 dependent genes shown in Figure 3
From: Identification of novel Cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo
Gene | Function. Remarks | Reference |
|---|---|---|
Galr1 | Receptor for galanin, pain perception, inhibits basal and gastrin-induced acid secretion | Â |
Tjp1 | Tight junction protein, epithelial integrity. H. pylori interaction | [57] |
Gdf3 | Regulator of cell growth and differentiation | Â |
Igf2 | Cell growth/control | [40] |
Ifngr | Inflammation | [46] |
Planh2. Serpinb2 | Inhibits plasminogen activator. important role in cell matrix degradation. gastrin dependent | |
Ptch | Cell fate. tumor suppressor | Â |
Mycs | Oncogene. mediates apoptosis | [37] |
Tff1 | Protects mucosa from insults. stabilizes mucus layer. epithelial healing. suppresses proliferation | [39] |
Iigp- pend. & Igtp | Regulates anti-microbial activities of IFNγ in a STAT 1 dependent manner |  |
Spi1-1-3 | Tissue scavenger of leukocyte elastase | Â |
Aqp5 | Water transport. | Â |
Gast | Regulation of gastric acid secretion. Growth factor activity in gastric mucosa. Selective inhibition of Cox-2 reverses trophic activity. | |
Hspa1a | Heat shock protein, chaperone. | Â |
Icam1 | Mediates lymphocyte migration. | |
Sell. L-selectin | Mediates lymphocyte migration | [50] |
Clu | Inhibits apoptosis, levels elevated in both mouse and human tumours | Â |
Ly64, MUC13 | In concert with TLR4, controls B cell recognition and signalling of lipopolysaccharide (LPS) | Â |
Ambp, bikunin | Suppresses urokinase expression and tumour metastasis | [38] |
Ddb1 | DNA repair protein | Â |
Defcr | Anti microbial peptide | [25] |