Table 3 Function of selected Cox-2 dependent genes shown in Figure 3
From: Identification of novel Cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo
| Gene | Function. Remarks | Reference |
|---|---|---|
| Galr1 | Receptor for galanin, pain perception, inhibits basal and gastrin-induced acid secretion | |
| Tjp1 | Tight junction protein, epithelial integrity. H. pylori interaction | [57] |
| Gdf3 | Regulator of cell growth and differentiation | |
| Igf2 | Cell growth/control | [40] |
| Ifngr | Inflammation | [46] |
|
Planh2. Serpinb2 | Inhibits plasminogen activator. important role in cell matrix degradation. gastrin dependent | [32, 30] |
| Ptch | Cell fate. tumor suppressor | |
| Mycs | Oncogene. mediates apoptosis | [37] |
| Tff1 | Protects mucosa from insults. stabilizes mucus layer. epithelial healing. suppresses proliferation | [39] |
|
Iigp- pend. & Igtp | Regulates anti-microbial activities of IFNγ in a STAT 1 dependent manner | |
| Spi1-1-3 | Tissue scavenger of leukocyte elastase | |
| Aqp5 | Water transport. | |
| Gast | Regulation of gastric acid secretion. Growth factor activity in gastric mucosa. Selective inhibition of Cox-2 reverses trophic activity. | [31, 33, 34] |
| Hspa1a | Heat shock protein, chaperone. | |
| Icam1 | Mediates lymphocyte migration. | [48, 49] |
|
Sell. L-selectin | Mediates lymphocyte migration | [50] |
| Clu | Inhibits apoptosis, levels elevated in both mouse and human tumours | |
| Ly64, MUC13 | In concert with TLR4, controls B cell recognition and signalling of lipopolysaccharide (LPS) | |
| Ambp, bikunin | Suppresses urokinase expression and tumour metastasis | [38] |
| Ddb1 | DNA repair protein | |
| Defcr | Anti microbial peptide | [25] |