Figure 2From: Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotionHeatmap of identified clusters. SENCAR mouse skin was treated with TPA or TPA + ATRA. Expression of genes induced ≥ 1.5-fold by TPA treatment compared to controls (C1A-C subclusters) and suppressed ≥ 1.5 fold by TPA (C2A-C) are indicated in green-red scale (green = low expression, red = high expression, black = intermediate expression). Expression patterns of genes for each subgroup are shown in graphs on the right, in which the raw scores were normalized to a mean value of 0 and a standard deviation of 1.Back to article page