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Figure 1 | Molecular Cancer

Figure 1

From: siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells

Figure 1

Doxorubicin resistance and expression of antiapoptotic protein and P-glycoprotein in chondrosarcoma cells. (A) Detection of apoptosis by flow cytometry after doxorubicin treatment. Two normal articular chondrocytes (NC1 and NC2) and two chondrosarcoma cells (SW: SW1353 and JJ: JJ012) showed chemoresistance when compared to human embryonic kidney cells (HEK). (B) Immunoblotting anti-apoptotic proteins (Bcl-2, Bcl-xL, and XIAP) and P-glycoprotein. Bcl-2, Bcl-xL, XIAP and P-glycoprotein expressions were verified in two normal chondrocytes (NC1 and NC2) and two chondrosarcoma cells (SW: SW1353, JJ: JJ012). (C) Immunoblotting anti-apoptotic proteins (Bcl-2, Bcl-xL, and XIAP) and P-glycoprotein in two chondrosarcoma cells after doxorubicin treatment. Bcl-2, Bcl-xL, XIAP and P-glycoprotein expressions were not changed significantly after doxorubicin treatment.

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